IDENTIFICATION OF HOST FACTORS INVOLVED IN HUMAN CYTOMEGALOVIRUS REPLICATION, ASSEMBLY, AND EGRESS USING A TWO-STEP SMALL INTERFERING RNA SCREEN

Identification of Host Factors Involved in Human Cytomegalovirus Replication, Assembly, and Egress Using a Two-Step Small Interfering RNA Screen

ABSTRACT As obligate intracellular parasites, viruses are completely dependent on host factors for replication.Assembly and egress of complex virus particles, such as human cytomegalovirus (HCMV), are likely to require many host factors.Despite this, relatively few have been identified and characterized.This study describes a novel high-throughput,

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Astrocyte-specific hypoxia-inducible factor 1 (HIF-1) does not disrupt the endothelial barrier during hypoxia in vitro

Abstract Background Astrocytes (AC) are essential for brain homeostasis.Much data suggests that AC support and protect the vascular endothelium, but increasing evidence indicates that during injury conditions they may lose their supportive role resulting in endothelial cell activation and BBB disturbance.Understanding the triggers that flip this sw

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INTERACTION ANALYSIS OF THE CONSOLE KNIFE SURFACE WITH THE SOIL

Introduction.In Russia the use of cyclical equipment to remove the top layer of the soil is not feasible.The problem of the roads construction accelerating, improving their quality can be solved by applying a continuous action unit to form a litter layer.The main working bodies of the unit are buckets, including lower knives, right knives and conso

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